ASSISTDesign            A class to encapsulate the adaptive clinical
                        trial design of Lai, Lavori and Liao
ASSISTDesignB           A fixed sample design to compare against the
                        adaptive clinical trial design
ASSISTDesignC           A fixed sample RCT design to compare against
                        the adaptive clinical trial design of Lai,
                        Lavori and Liao.
ASSISTant               Three stage group sequential adaptive design
                        with subgroup selection
DEFUSE3Design           The DEFUSE3 design
LLL.SETTINGS            Design and trial settings used in the Lai,
                        Lavori, Liao paper simulations
colNamesForStage        Return a vector of column names for statistics
                        for a given stage
computeMHPBoundaries    Compute the three modified Haybittle-Peto
                        boundaries
computeMHPBoundaryITT   Compute the three modified Haybittle-Peto
                        boundaries and effect size
computeMeanAndSD        Compute the mean and sd of a discrete Rankin
                        distribution
conformParameters       Conform designParameters so that weights are
                        turned in to probabilities, the null and
                        control distributions are proper matrices etc.
generateDiscreteData    A data generation function using a discrete
                        distribution for Rankin score rather than a
                        normal distribution
generateNormalData      A data generation function along the lines of
                        what was used in the Lai, Lavori, Liao paper.
                        score rather than a normal distribution
groupSampleSize         Compute the sample size for any group at a
                        stage assuming a nested structure as in the
                        paper.
mHP.b                   Compute the efficacy boundary (modified
                        Haybittle-Peto) for the first two stages
mHP.btilde              Compute the futility boundary (modified
                        Haybittle-Peto) for the first two stages
mHP.c                   Compute the efficacy boundary (modified
                        Haybittle-Peto) for the final (third) stage
wilcoxon                Compute the standardized Wilcoxon test
                        statistic for two samples
