Exploratory Subgroup Identification in Clinical Trials with Survival Endpoints

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Documentation for package ‘forestsearch’ version 0.1.0

• DESCRIPTION file
• User guides, package vignettes and other documentation
• Package NEWS
• Package README

Help Pages

build_classification_table	Build Classification Rate Table from Simulation Results
build_estimation_table	Build Estimation Properties Table from Simulation Results
calibrate_cens_adjust	Calibrate Censoring Adjustment to Match DGM Reference Distribution
calibrate_k_inter	Calibrate k_inter for Target Subgroup Hazard Ratio
check_censoring_dgm	Diagnose Censoring Consistency Between DGM Source Data and Simulated Data
compute_detection_probability	Compute Probability of Detecting True Subgroup
compute_dgm_cde	Compute and Attach CDE Values to a DGM Object
cox_ahr_cde_analysis	Comprehensive Wrapper for Cox Spline Analysis with AHR and CDE Plotting
cox_cs_fit	Fit Cox Model with Cubic Spline for Treatment Effect Heterogeneity
cox_summary	Cox model summary for subgroup (OPTIMIZED)
create_dgm_for_mrct	Create Data Generating Mechanism for MRCT Simulations
create_forest_theme	Create Forest Plot Theme with Size Controls
create_summary_table	Create Enhanced Summary Table for Baseline Characteristics
cv_metrics_tables	Create Metrics Tables for Cross-Validation Results
cv_summary_tables	Create Summary Tables from forestsearch_KfoldOut Results
figure_note	Generate Figure Note for Quarto/RMarkdown
forestsearch	ForestSearch: Exploratory Subgroup Identification
forestsearch_bootstrap_dofuture	ForestSearch Bootstrap with doFuture Parallelization
forestsearch_Kfold	ForestSearch K-Fold Cross-Validation
forestsearch_KfoldOut	ForestSearch K-Fold Cross-Validation Output Summary
forestsearch_tenfold	ForestSearch Repeated K-Fold Cross-Validation
format_oc_results	Format Operating Characteristics Results as GT Table
generate_aft_dgm_flex	Generate Synthetic Survival Data using AFT Model with Flexible Subgroups
generate_detection_curve	Generate Detection Probability Curve
gg_forest	ggplot2 / patchwork forest plot
grf.subg.harm.survival	GRF Subgroup Identification for Survival Data
interpret_estimation_table	Generate Narrative Interpretation of Estimation Properties
mrct_region_sims	MRCT Regional Subgroup Simulation
plot.forestsearch	Plot ForestSearch Results
plot_detection_curve	Plot Detection Probability Curve
plot_km_band_forestsearch	Plot Kaplan-Meier Survival Difference Bands for ForestSearch Subgroups
plot_sg_weighted_km	Plot Weighted Kaplan-Meier Curves for ForestSearch Subgroups
plot_spline_treatment_effect	Plot Spline Treatment Effect Function
plot_subgroup_results_forestplot	Plot Subgroup Results Forest Plot
print.cox_ahr_cde	Print method for cox_ahr_cde objects
print.forestsearch	Print Method for forestsearch Objects
print.fs_kfold	Print Method for K-Fold CV Results
print.fs_tenfold	Print Method for Repeated K-Fold CV Results
print.gbsg_dgm	Print Method for gbsg_dgm Objects
render_forestplot	Render ForestSearch Forest Plot
render_reference_table	Render Reference Simulation Table as gt
run_simulation_analysis	Run One Simulation Replicate
select_best_subgroup	Select best subgroup based on criterion
setup_gbsg_dgm	Set Up a GBSG-Based AFT Data Generating Mechanism
sg_tables	Enhanced Subgroup Summary Tables (gt output)
simulate_from_dgm	Simulate Survival Data from AFT Data Generating Mechanism
subgroup.consistency	Evaluate Subgroup Consistency
summarize_bootstrap_events	Summarize Bootstrap Event Counts
summarize_bootstrap_results	Enhanced Bootstrap Results Summary
summarize_simulation_results	Summarize Simulation Results
summary.cox_ahr_cde	Summary method for cox_ahr_cde objects
summary.forestsearch	Summary Method for forestsearch Objects
validate_k_inter_effect	Validate k_inter Effect on HR Heterogeneity